题目：Force Spectroscopy: from single molecule to two molecules to tissues

报告人：Hongbin Li

邀请人：雷海

时间：2025年11月6日（周四）上午10点

地点：紫金港校区海纳苑8幢215报告厅

摘要：

Over the last thirty years, the development of single molecule techniques has dramatically changed the landscape of a myriad of disciplines, including chemistry and biophysics. Amongst single molecule techniques, single molecule force spectroscopy offers a mechanical approach to investigate the dynamics of chemical/biochemical processes and has elucidated insights that are otherwise difficult to obtain. In this talk, I will first present the latest progress of single molecule force spectroscopy, and then discuss the limitation of single molecule force spectroscopy and highlight the need to develop techniques that can probe the mechanical properties of parallelly or anti-parallelly arranged protein multimers that exist under physiological conditions. I will present our latest results on giant muscle protein titin obtained using two-molecule force spectroscopy. 

个人简介：

Dr. Hongbin Li is currently a Professor at the Department of Chemistry, the University of British Columbia, Canada, and Director of the NSERC CREATE Program on 3D Printing Technology and Materials (3DPTM). He held the position of Canada Research Chair in Molecular Nanoscience and Protein Engineering from 2004-2014. Prior to joining UBC, he worked as an Associate Research Scientist in Columbia University (2002-2004) and a postdoctoral research fellow in Mayo Medical Center (1999-2002). He obtained his Ph.D. in Jilin University in 1998 and B.S. at Tianjin University in 1993. His research interest is in the area of single molecule biophysics, single molecule force spectroscopy and protein-based biomaterials. He is an elected Fellow of American Associate for the Advancement of Science (AAAS Fellow). His contributions have been recognized by Charles McDowell Award in Research, NSERC Accelerator Award, Career Investigator Award from Michael Smith Foundation, JILA Distinguished Fellowship.